Some recollections and reflections on mutation rates.
نویسنده
چکیده
I take this opportunity to record some of my own In general, the growth rate of a bacterial strain may be recollections of the work on mutation in the 1940s and within very wide limits independent of the concentration early 1950s that was so influential in the development of a given growth factor; but since at zero concentration of quantitative biology. In 1943, Luria and Delbrück the growth rate is zero, there must of necessity exist, at sufficiently low concentrations of the growth factor, a had elegantly shown that mutation could occur prior region in which the growth rate falls with falling concento the selection process used to detect its products. In tration of the growth factor. It therefore should be possi1944, Avery et al. had shown that the chemical material ble to maintain a bacterial population over an indefinite responsible for the transfer of genetic properties from period of time growing at a rate considerably lower than one bacterium to another (bacterial transformation) normal simply by maintaining the concentration of one growth factor—the controlling growth factor—at a suffiwas DNA, but the general implications of this demonciently low value, while the concentrations of all other stration were still regarded with suspicion. The proposal growth factors may at the same time be maintained at by Watson and Crick (1953) for the molecular struchigh values. (p. 708) ture of DNA was still in the future. In retrospect, our
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عنوان ژورنال:
- Genetics
دوره 148 4 شماره
صفحات -
تاریخ انتشار 1998